Tyrosine metabolic process

Across TCGA cell cohorts, RNA activity of the Tyrosine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRICKLE3, FAH, and NAA40, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tyrosine metabolic process activity versus PRICKLE3 in BLOOD_Leukemia (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRICKLE3 →	+0.698	+1.092	<.001	.004	3	4
BLOOD_Lymphoma	FAH →	+1.389	+1.343	.002	.003	3	4
BLOOD_Lymphoma	NAA40 →	-0.767	-1.575	.002	.002	3	4
BLOOD_Lymphoma	APBB1IP →	-3.554	-1.530	<.001	<.001	3	3
BLOOD_Lymphoma	HMOX1 →	+2.428	+1.245	.002	.003	3	3
BLOOD_Leukemia	CTCF →	-0.924	-1.606	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006570 vs PRICKLE3 — BLOOD_Leukemia

Explore this scatter interactively →