Tryptophan catabolic process

Across TCGA patient cohorts, RNA activity of the Tryptophan catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC15A3, TRBC1, and CD2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tryptophan catabolic process activity versus SLC15A3 in GBM (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SLC15A3 →	+0.706	+0.341	<.001	.003	3	7
HNSC	TRBC1 →	+1.325	+0.206	<.001	<.001	3	7
HNSC	CD2 →	+1.049	+0.178	.004	.006	3	7
LSCC	CD96 →	+0.748	+0.111	<.001	<.001	3	7
HNSC	CCR5 →	+0.997	+0.202	.001	.001	3	7
HNSC	SNX20 →	+0.691	+0.173	.002	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006569 vs SLC15A3 — GBM

Explore this scatter interactively →