Q-omics provides the consensus-scored TRBC1 profile across patient tissues and cancer cell-line models. TRBC1 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, TRBC1 is differentially expressed in 7, with the highest sampling consensus in KIRC. Additionally, TRBC1 RNA expression shows 19,052 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight HNSC, KIRC, and LSCC as cancer lineages where TRBC1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TRBC1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TRBC1 survival associations across molecular data types. TRBC1 RNA expression shows survival associations in the most cancer types (24). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TRBC1 RNA expression–survival associations across cancer types. High TRBC1 expression shows unfavorable associations in UVM, but favorable associations in HNSC, SKCM, LUAD, CESC and UCEC. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for TRBC1 RNA expression.
This table summarizes TRBC1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7, while mass-spec protein shows differences in 1. The strongest signals are observed in KIRC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for TRBC1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TRBC1 shows lower tumor expression in COAD and LUSC and higher tumor expression in KIRC, BRCA, STAD and THCA. The KIRC box plot shows higher TRBC1 RNA expression in tumor versus normal tissue (log2 FC = +1.290, t-test p < 0.001).
This table shows molecular features associated with TRBC1 in patient tissues and cancer cell lines. In patient samples, TRBC1 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set.
