Tryptophan metabolic process

Across TCGA patient cohorts, RNA activity of the Tryptophan metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FOXK1_S253, CHGB_S130, and REL, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tryptophan metabolic process activity versus FOXK1_S253 in BRCA (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FOXK1_S253 →	+1.149	+1.105	<.001	.002	3	3
BRCA	CHGB_S130 →	-2.505	-0.793	<.001	<.001	3	3
GBM	REL →	+0.250	+0.541	<.001	<.001	3	2
GBM	SYNPO2_S604 →	+0.650	+0.983	<.001	<.001	3	2
GBM	SYNPO2_S781 →	+0.812	+0.847	<.001	<.001	3	2
GBM	TTPAL_S13 →	-1.699	-1.652	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006568 vs FOXK1_S253 — BRCA

Explore this scatter interactively →