Threonine metabolic process

Across TCGA patient cohorts, RNA activity of the Threonine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SDS, PHGDH, and MTA1_S449, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Threonine metabolic process activity versus SDS in COAD (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SDS →	+1.004	+0.066	<.001	.002	3	9
COAD	PHGDH →	+0.721	+0.056	<.001	<.001	3	7
PDAC	MTA1_S449 →	-0.618	-0.076	<.001	.001	3	6
CCRCC	SHROOM4_S299 →	-0.392	-0.065	.009	.002	3	5
COAD	ASNS →	+0.601	+0.047	<.001	.002	2	6
COAD	ATP6V1F →	+0.244	+0.064	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006566 vs SDS — COAD

Explore this scatter interactively →