Threonine metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Threonine metabolic process pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher Threonine metabolic process pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as MESO and READ, show the opposite pattern, with higher activity associated with better survival.

UCS, THYM, and UCEC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	II,III,IV	0.433	0.868	.002	34	view →
THYM	OS	Median	All	0.802	1.000	.020	30	view →
UCEC	OS	Quartile	III,IV	0.715	0.892	.009	26	view →
COAD	DFS	Tertile	III,IV	0.315	0.524	.004	25	view →
STAD	OS	Quartile	All	0.305	0.485	.019	24	view →
UVM	DFS	Quartile	II,III,IV	0.315	0.631	.019	21	view →
LUSC	DFS	Tertile	II,III,IV	0.605	0.801	<.001	18	view →
GBM	OS	Tertile	All	0.280	0.556	.008	15	view →
THCA	OS	Quartile	II,III,IV	0.904	1.000	.007	12	view →
PCPG	DFS	Median	All	0.800	1.000	.001	10	view →
MESO	DFS	Tertile	IV	0.578	0.161	.011	9	view →
HNSC	OS	Tertile	All	0.286	0.369	.014	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0006566–UCS (OS)

Open the UCS breakdown →