Threonine metabolic process

Across TCGA patient cohorts, RNA activity of the Threonine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TYW5, ST6GAL1, and HVCN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Threonine metabolic process activity versus TYW5 in UCEC (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TYW5 →	-0.457	-0.190	<.001	<.001	3	4
GBM	ST6GAL1 →	+0.725	+0.119	.001	<.001	3	4
HNSC	HVCN1 →	+0.557	+0.149	.002	.001	3	4
LSCC	FAM210A →	-0.599	-0.339	<.001	.002	3	4
PDAC	TMEM158 →	-0.909	-0.208	<.001	<.001	3	4
CCRCC	MAGOHB →	-0.200	-0.165	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006566 vs TYW5 — UCEC

Explore this scatter interactively →