Threonine metabolic process

Across TCGA patient cohorts, RNA activity of the Threonine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SDSL, USP32_S1588, and FASTKD3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Threonine metabolic process activity versus SDSL in GBM (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SDSL →	+0.549	+0.111	<.001	<.001	3	4
UCEC	USP32_S1588 →	-0.630	-0.231	<.001	<.001	3	3
OV	FASTKD3 →	-0.859	-0.174	.004	.003	3	3
OV	BAHD1_S121 →	+1.103	+0.275	<.001	<.001	3	3
BRCA	MAP1S_S731 →	+0.342	+0.104	<.001	.002	3	3
BRCA	PKN3_S544 →	-0.773	-0.176	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006566 vs SDSL — GBM

Explore this scatter interactively →