Threonine metabolic process

Across TCGA cell cohorts, RNA activity of the Threonine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TATDN1, MICAL1, and VBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TATDN1 grouped by Threonine metabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TATDN1 →	+0.832	+0.991	.001	.007	3	5
SKIN	MICAL1 →	-2.080	-1.216	<.001	.002	3	4
SKIN	VBP1 →	+0.716	+1.516	.002	<.001	3	4
SKIN	DENND6A →	+0.574	+1.142	<.001	.001	3	4
BLOOD_Leukemia	POLA1 →	+0.840	+1.195	.006	.001	3	4
LUNG_SCLC	NFYC →	-1.004	-1.062	.007	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TATDN1 by Threonine metabolic process activity — SKIN

Explore this box plot interactively →