Threonine metabolic process

Across TCGA cell cohorts, RNA activity of the Threonine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCAT, SDSL, and CCDC113, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Threonine metabolic process activity versus GCAT in OESOPHAGUS (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GCAT →	+1.600	+0.163	<.001	<.001	3	17
URINARY_TRACT	SDSL →	+1.319	+0.146	.001	.001	2	11
LARGE_INTESTINE	CCDC113 →	+0.712	+0.112	.003	.006	3	8
LUNG_NSCLC_LUAD	TXN2 →	+0.401	+0.113	.006	<.001	3	8
LUNG_NSCLC_LUSC	ZFHX3 →	-0.848	-0.207	.002	.004	3	7
SKIN	POLR2F →	+0.844	+0.118	.007	.009	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006566 vs GCAT — OESOPHAGUS

Explore this scatter interactively →