Threonine metabolic process

Across TCGA cell cohorts, RNA activity of the Threonine metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPRF, PDAP1, and RBX1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPRF grouped by Threonine metabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PTPRF →	+0.234	+1.594	.002	<.001	3	3
PANCREAS	PDAP1 →	+0.250	+1.681	.005	<.001	3	3
SKIN	RBX1 →	+0.423	+1.060	<.001	.007	3	2
SKIN	OASL →	+0.344	+1.211	.005	.008	3	2
SKIN	KCNS2 →	-0.127	-1.421	.008	.001	3	2
LUNG_NSCLC_LUAD	ATP11A →	+0.172	+1.267	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPRF by Threonine metabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →