L-serine catabolic process

Across TCGA cell cohorts, RNA activity of the L-serine catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BYSL, OS9, and TTC21A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BYSL grouped by L-serine catabolic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BYSL →	+0.781	+1.093	.003	.009	3	4
BLOOD_Leukemia	OS9 →	-0.608	-0.942	<.001	.009	3	4
BLOOD_Leukemia	TTC21A →	+0.712	+1.115	<.001	.001	3	4
BLOOD_Leukemia	NDC80 →	+0.919	+1.332	.002	.002	3	4
BONE	LYRM9 →	-2.086	-1.478	.001	<.001	3	4
SKIN	CWF19L1 →	+0.524	+1.177	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BYSL by L-serine catabolic process activity — BLOOD_Leukemia

Explore this box plot interactively →