L-serine biosynthetic process

Across TCGA cell cohorts, RNA activity of the L-serine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFV3, MFSD1, and PLA2G4C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDUFV3 grouped by L-serine biosynthetic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NDUFV3 →	-0.602	-0.874	.001	.003	3	5
LUNG_SCLC	MFSD1 →	-1.002	-0.285	.003	<.001	3	4
LUNG_NSCLC_LUAD	PLA2G4C →	-0.722	-0.392	.009	.005	3	3
SKIN	MAN2B1 →	-0.828	-1.263	<.001	<.001	3	3
PANCREAS	TCTA →	-0.726	-0.266	.003	.004	2	4
PANCREAS	CHRFAM7A →	+0.685	+0.244	.003	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDUFV3 by L-serine biosynthetic process activity — SKIN

Explore this box plot interactively →