L-serine metabolic process

Across TCGA patient cohorts, RNA activity of the L-serine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POGLUT1, MBOAT2, and RN7SL555P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-serine metabolic process activity versus POGLUT1 in CCRCC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	POGLUT1 →	-0.190	-0.118	.007	.001	3	4
PDAC	MBOAT2 →	-0.424	-0.138	.002	.001	3	3
PDAC	RN7SL555P →	+0.681	+0.154	.005	.002	3	3
HNSC	GDPD2 →	-0.837	-0.079	.005	.006	3	3
HNSC	USP6NL →	+0.537	+0.085	.002	.002	2	4
HNSC	LGALS9C →	-0.819	-0.101	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006563 vs POGLUT1 — CCRCC

Explore this scatter interactively →