Proline metabolic process

Across TCGA patient cohorts, RNA activity of the Proline metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAM1B, ACACA, and PRODH, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proline metabolic process activity versus ADAM1B in BRCA (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ADAM1B →	+0.241	+0.095	.001	.004	3	6
LSCC	ACACA →	+0.543	+0.118	<.001	<.001	3	6
LUAD	PRODH →	+1.659	+0.138	<.001	<.001	3	5
HNSC	SLC52A1 →	+0.796	+0.131	<.001	.002	3	5
LSCC	KIAA0895 →	+0.474	+0.081	<.001	.002	3	5
LUAD	FAM234A →	+0.499	+0.135	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006560 vs ADAM1B — BRCA

Explore this scatter interactively →