Methionine metabolic process

Across TCGA patient cohorts, RNA activity of the Methionine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTPN1, MTAP, and SH3BP4_S241, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Methionine metabolic process activity versus PTPN1 in CCRCC (Pearson r = -0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PTPN1 →	-0.390	-0.066	<.001	<.001	3	5
GBM	MTAP →	+0.624	+0.040	<.001	.004	3	5
PDAC	SH3BP4_S241 →	+0.572	+0.049	.003	<.001	3	4
PDAC	SUPT16H_S650 →	-0.986	-0.067	<.001	<.001	3	4
BRCA	TSHZ1_T852 →	+0.512	+0.043	<.001	<.001	3	4
BRCA	DLC1_S1254 →	+1.115	+0.048	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006555 vs PTPN1 — CCRCC

Explore this scatter interactively →