L-leucine metabolic process

Across TCGA cell cohorts, RNA activity of the L-leucine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHPK, INO80C, and HLA-DPA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SHPK grouped by L-leucine metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SHPK →	+0.691	+1.007	.001	.001	3	4
OVARY	INO80C →	+0.636	+0.700	<.001	.009	3	4
CNS	HLA-DPA1 →	+2.480	+0.881	<.001	<.001	3	3
OESOPHAGUS	C18orf21 →	+0.865	+0.864	<.001	.007	2	4
OESOPHAGUS	METAP1D →	+0.619	+0.748	.001	.004	3	3
CNS	EXOSC3 →	+0.659	+0.999	.009	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SHPK by L-leucine metabolic process activity — CNS

Explore this box plot interactively →