Glycine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Glycine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCAF4L1, CMTM3, and MESD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DCAF4L1 grouped by Glycine biosynthetic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DCAF4L1 →	+0.267	+1.273	.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	CMTM3 →	+1.331	+1.348	.004	<.001	3	4
SOFT_TISSUE	MESD →	-0.882	-1.345	.002	<.001	3	4
CNS	HIBADH →	-0.801	-1.082	.005	.002	3	4
BLOOD_Lymphoma	NAV1 →	+1.382	+1.650	<.001	.004	3	4
OVARY	RNMT →	+0.548	+0.917	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DCAF4L1 by Glycine biosynthetic process activity — LARGE_INTESTINE

Explore this box plot interactively →