Glycine metabolic process

Across TCGA patient cohorts, RNA activity of the Glycine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PHGDH, SHMT1, and TIMP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycine metabolic process activity versus PHGDH in LUAD (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PHGDH →	+0.786	+0.089	<.001	<.001	3	8
OV	SHMT1 →	+0.524	+0.055	<.001	<.001	3	7
CCRCC	TIMP2 →	-0.545	-0.061	<.001	.001	3	6
PDAC	ACTB →	-0.555	-0.053	<.001	.002	3	6
BRCA	CAVIN3 →	-0.463	-0.041	.007	.003	2	7
OV	CNN2 →	-0.578	-0.055	.003	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006544 vs PHGDH — LUAD

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