Glycine metabolic process

Across TCGA patient cohorts, RNA activity of the Glycine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAD21, RAD54B, and RTL8C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycine metabolic process activity versus RAD21 in BRCA (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RAD21 →	+0.688	+0.116	.006	.003	3	4
UCEC	RAD54B →	+0.492	+0.141	.006	.002	3	4
OV	RTL8C →	-0.773	-0.185	<.001	.003	3	4
BRCA	SLC39A13 →	-0.606	-0.139	<.001	<.001	3	4
GBM	RNF2P1 →	+0.611	+0.158	<.001	.001	3	4
OV	RN7SL25P →	+0.319	+0.153	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006544 vs RAD21 — BRCA

Explore this scatter interactively →