Glycine metabolic process

Across TCGA cell cohorts, RNA activity of the Glycine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCSH, APRT, and DHODH, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycine metabolic process activity versus GCSH in LUNG_NSCLC_LUAD (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GCSH →	+1.770	+0.270	<.001	<.001	3	7
LARGE_INTESTINE	APRT →	+0.740	+0.204	<.001	<.001	3	6
BLOOD_Lymphoma	DHODH →	+0.557	+0.172	.002	.001	3	6
LUNG_NSCLC_LUAD	CTU2 →	+0.637	+0.226	.005	.001	3	5
CNS	VPS37A →	-0.830	-0.232	.009	.004	3	5
CNS	PTTG1 →	-0.662	-0.195	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006544 vs GCSH — LUNG_NSCLC_LUAD

Explore this scatter interactively →