Glutamine metabolic process

Across TCGA patient cohorts, RNA activity of the Glutamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAGI1, XPA, and EPB41L1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutamine metabolic process activity versus MAGI1 in GBM (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MAGI1 →	-0.711	-0.164	<.001	<.001	3	8
LSCC	XPA →	-0.499	-0.139	<.001	<.001	3	8
LUAD	EPB41L1 →	-0.669	-0.192	<.001	.004	3	7
BRCA	ZFP62 →	-0.463	-0.161	.003	.002	3	7
GBM	EPM2A →	-0.433	-0.120	<.001	<.001	3	6
HNSC	RALGPS1 →	-0.719	-0.179	.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006541 vs MAGI1 — GBM

Explore this scatter interactively →