Glutamine metabolic process

Across TCGA cell cohorts, RNA activity of the Glutamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLD3, PNPLA3, and PLEKHG4B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLD3 grouped by Glutamine metabolic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PLD3 →	-0.988	-1.101	.002	.002	3	5
STOMACH	PNPLA3 →	-1.928	-0.436	<.001	<.001	3	4
STOMACH	PLEKHG4B →	-1.520	-0.253	.001	.006	3	4
STOMACH	FBXO17 →	-4.128	-0.360	<.001	<.001	3	4
LARGE_INTESTINE	FGD3 →	-1.607	-0.933	.009	.003	3	4
LARGE_INTESTINE	STARD4 →	-1.206	-0.764	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLD3 by Glutamine metabolic process activity — SOFT_TISSUE

Explore this box plot interactively →