Asparagine metabolic process

Across TCGA patient cohorts, RNA activity of the Asparagine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NIT2, ASRGL1, and HID1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Asparagine metabolic process activity versus NIT2 in LUAD (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NIT2 →	+0.219	+0.095	<.001	<.001	3	6
OV	ASRGL1 →	+0.851	+0.079	.002	<.001	3	5
COAD	HID1 →	+0.436	+0.048	.001	.003	3	5
GBM	CALU →	-0.463	-0.047	<.001	.001	3	5
LSCC	SPATA33 →	+0.539	+0.061	<.001	<.001	3	5
LSCC	TOMM70 →	+0.291	+0.044	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006528 vs NIT2 — LUAD

Explore this scatter interactively →