Arginine catabolic process

Across TCGA cell cohorts, RNA activity of the Arginine catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WFDC2, LAMA1, and SH3PXD2A, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Arginine catabolic process activity versus WFDC2 in OVARY (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	WFDC2 →	+8.201	+0.404	.001	.006	3	1
OVARY	LAMA1 →	+3.328	+0.392	.008	.006	3	1
OVARY	SH3PXD2A →	-2.054	-0.314	.006	.003	3	1
OVARY	COX7A2 →	+1.025	+0.308	.006	.004	3	1
OVARY	EFHD1 →	+4.973	+0.470	<.001	.002	3	1
OVARY	TESMIN →	+1.063	+0.308	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006527 vs WFDC2 — OVARY

Explore this scatter interactively →