Arginine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Arginine biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KATNB1, MST1R, and CNGA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KATNB1 grouped by Arginine biosynthetic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	KATNB1 →	+0.319	+0.278	.001	<.001	3	4
OVARY	MST1R →	+0.206	+0.268	.004	.001	3	4
STOMACH	CNGA2 →	+0.200	+0.333	.001	<.001	3	4
BLOOD_Myeloma	GATA6 →	-0.256	-0.226	.001	.002	3	4
LARGE_INTESTINE	OR5P3 →	-0.307	-0.243	.001	.002	2	5
OESOPHAGUS	RAB18 →	+0.147	+0.189	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KATNB1 by Arginine biosynthetic process activity — URINARY_TRACT

Explore this box plot interactively →