Regulation of cellular amino acid metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of cellular amino acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC7A7, TYROBP, and HAVCR2, each associated with the pathway in up to 23 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular amino acid metabolic process activity versus SLC7A7 in LAML (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	SLC7A7 →	+2.480	+0.202	<.001	<.001	3	23
LAML	TYROBP →	+1.633	+0.180	<.001	<.001	3	21
SARC	HAVCR2 →	+1.262	+0.055	<.001	<.001	3	21
LGG	TREM2 →	+1.275	+0.039	<.001	<.001	3	21
LAML	LY86 →	+1.719	+0.156	<.001	<.001	3	20
LAML	CD86 →	+2.292	+0.174	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006521 vs SLC7A7 — LAML

Explore this scatter interactively →