Regulation of cellular amino acid metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of cellular amino acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBXAS1, ATP6V0D1, and CYBB, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular amino acid metabolic process activity versus TBXAS1 in GBM (Pearson r = -0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TBXAS1 →	+0.458	+0.100	.001	<.001	3	8
LSCC	ATP6V0D1 →	+0.208	+0.077	<.001	<.001	3	8
GBM	CYBB →	+0.540	+0.089	<.001	<.001	3	7
GBM	HCK →	+0.481	+0.091	<.001	<.001	3	7
GBM	AMPD3 →	+0.521	+0.082	<.001	<.001	3	7
GBM	ITGB2 →	+0.507	+0.093	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006521 vs TBXAS1 — GBM

Explore this scatter interactively →