Regulation of cellular amino acid metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of cellular amino acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB7C, ZNF829, and BCKDK, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular amino acid metabolic process activity versus ZBTB7C in GBM (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ZBTB7C →	+0.580	+0.191	.005	<.001	3	4
GBM	ZNF829 →	-0.410	-0.178	.002	.003	3	4
BRCA	BCKDK →	+0.414	+0.086	.002	.008	3	3
LUAD	VPS35L →	+0.276	+0.548	.007	<.001	3	3
BRCA	KLRB1 →	-0.607	-0.122	.003	.003	3	3
LUAD	GPR52 →	-0.328	-0.483	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006521 vs ZBTB7C — GBM

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