Regulation of cellular amino acid metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of cellular amino acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA4G, TSPAN8, and ARHGAP42, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEMA4G grouped by Regulation of cellular amino acid metabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SEMA4G →	+1.776	+1.294	<.001	<.001	3	5
LARGE_INTESTINE	TSPAN8 →	+4.151	+1.295	<.001	<.001	3	5
SOFT_TISSUE	ARHGAP42 →	-1.678	-1.147	.004	.002	3	4
BONE	ATF5 →	+2.019	+1.501	<.001	.002	3	4
SOFT_TISSUE	CES4A →	+2.138	+1.585	<.001	<.001	3	4
SOFT_TISSUE	CA11 →	+2.732	+1.199	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEMA4G by Regulation of cellular amino acid metabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →