Regulation of cellular amino acid metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of cellular amino acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLS, APOBEC3F, and PKNOX1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular amino acid metabolic process activity versus GLS in LUNG_NSCLC_LUAD (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GLS →	+1.915	+0.292	<.001	<.001	3	8
LARGE_INTESTINE	APOBEC3F →	+1.220	+0.214	.007	.001	3	5
BLOOD_Leukemia	PKNOX1 →	+0.511	+0.112	.001	.003	3	5
OESOPHAGUS	GOLT1B →	+1.202	+0.217	<.001	.002	3	5
BREAST	PRKRA →	+0.739	+0.306	.001	<.001	3	5
BLOOD_Leukemia	SZRD1 →	+0.351	+0.102	.001	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006521 vs GLS — LUNG_NSCLC_LUAD

Explore this scatter interactively →