Amino acid metabolic process

Across TCGA patient cohorts, RNA activity of the Amino acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PMM2, LRPPRC, and UBE4A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino acid metabolic process activity versus PMM2 in PDAC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PMM2 →	+0.177	+0.017	.002	.001	3	6
LUAD	LRPPRC →	+0.398	+0.028	<.001	<.001	3	5
BRCA	UBE4A →	+0.254	+0.016	<.001	<.001	3	5
CCRCC	TBCK →	+0.183	+0.040	<.001	<.001	3	5
PDAC	WNK2_S1862 →	+0.656	+0.019	.001	<.001	3	5
OV	AIFM1 →	+0.434	+0.020	.007	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006520 vs PMM2 — PDAC

Explore this scatter interactively →