Amino acid metabolic process

Across TCGA patient cohorts, RNA activity of the Amino acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN6, TUBA1B, and LYAR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino acid metabolic process activity versus PTPN6 in PDAC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PTPN6 →	-0.606	-0.191	<.001	.002	3	5
BRCA	TUBA1B →	-0.624	-0.212	.001	<.001	3	4
PDAC	LYAR →	-0.483	-0.180	<.001	.004	3	4
HNSC	RFC5 →	-0.556	-0.171	<.001	<.001	3	4
HNSC	SMC4 →	-0.532	-0.124	.001	.001	3	4
BRCA	KIF11 →	-1.082	-0.233	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006520 vs PTPN6 — PDAC

Explore this scatter interactively →