Protein quality control for misfolded or incompletely synthesized proteins

Across TCGA patient cohorts, RNA activity of the Protein quality control for misfolded or incompletely synthesized proteins pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAPK6_S189, RPL10A, and RPL7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein quality control for misfolded or incompletely synthesized proteins activity versus MAPK6_S189 in BRCA (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MAPK6_S189 →	-0.566	-0.029	.001	.001	3	7
BRCA	RPL10A →	-0.167	-0.031	<.001	<.001	3	6
GBM	RPL7 →	-0.324	-0.045	.002	<.001	2	7
BRCA	TNS2_S120 →	+0.436	+0.037	.002	<.001	3	6
HNSC	MAP4_S696 →	-0.588	-0.063	<.001	.008	3	6
BRCA	TCEAL4 →	+0.674	+0.025	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006515 vs MAPK6_S189 — BRCA

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