Protein quality control for misfolded or incompletely synthesized proteins

Across TCGA pan-cancer cohorts, RNA activity of the Protein quality control for misfolded or incompletely synthesized proteins pathway is associated with patient survival in 18 of 34 cancer lineages. Pathway activity is summarized from the expression of its 31 member genes.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher Protein quality control for misfolded or incompletely synthesized proteins pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and UCS, show the opposite pattern, with higher activity associated with better survival.

BRCA, UVM, and LUSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Tertile	All	0.987	0.950	<.001	66	view →
UVM	DFS	Tertile	III,IV	0.223	0.744	.005	51	view →
LUSC	DFS	Tertile	III,IV	0.280	0.684	<.001	43	view →
UCS	DFS	Tertile	II,III,IV	0.502	0.100	.003	42	view →
KICH	DFS	Tertile	All	0.649	1.000	.007	39	view →
LGG	DFS	Median	All	0.781	0.879	<.001	37	view →
HNSC	DFS	Quartile	III,IV	0.589	0.254	.006	30	view →
SKCM	DFS	Quartile	All	0.343	0.171	<.001	27	view →
CHOL	DFS	Median	All	0.614	0.227	.005	19	view →
SCLC	DFS	Median	III,IV	0.550	0.228	.008	18	view →
THYM	DFS	Median	II,III,IV	0.863	0.619	.021	15	view →
DLBC	OS	Tertile	All	0.707	1.000	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GO:0006515–BRCA (OS)

Open the BRCA breakdown →