Protein quality control for misfolded or incompletely synthesized proteins

Across TCGA patient cohorts, RNA activity of the Protein quality control for misfolded or incompletely synthesized proteins pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAB1, INMT, and NOMO2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein quality control for misfolded or incompletely synthesized proteins activity versus GAB1 in CCRCC (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GAB1 →	-0.369	-0.205	<.001	<.001	3	5
CCRCC	INMT →	-1.098	-0.204	<.001	<.001	3	5
CCRCC	NOMO2 →	+0.450	+0.156	.001	<.001	3	5
CCRCC	PLSCR4 →	-0.568	-0.167	.001	.003	3	4
LUAD	PYCR3 →	+0.470	+0.118	.002	.002	3	4
UCEC	NEK2 →	+0.958	+0.153	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006515 vs GAB1 — CCRCC

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