Protein quality control for misfolded or incompletely synthesized proteins

Across TCGA cell cohorts, RNA activity of the Protein quality control for misfolded or incompletely synthesized proteins pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HEXD, PFKM, and IWS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein quality control for misfolded or incompletely synthesized proteins activity versus HEXD in LIVER (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	HEXD →	+1.184	+0.298	.004	.002	3	5
BLOOD_Leukemia	PFKM →	+1.525	+0.155	<.001	.001	3	5
LUNG_NSCLC_LUAD	IWS1 →	+0.494	+0.184	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	COX18 →	+0.794	+0.172	.008	.007	3	4
URINARY_TRACT	LYRM4 →	+0.911	+0.323	.003	.001	3	4
LIVER	PSPH →	+1.530	+0.260	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006515 vs HEXD — LIVER

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