Protein monoubiquitination

Across TCGA patient cohorts, RNA activity of the Protein monoubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XRCC2, TPX2, and DSN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein monoubiquitination activity versus XRCC2 in LSCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	XRCC2 →	+0.851	+1.050	.001	<.001	3	7
BRCA	TPX2 →	+0.966	+0.484	<.001	<.001	3	7
BRCA	DSN1 →	+0.542	+0.475	<.001	<.001	3	6
LSCC	RFC4 →	+0.716	+0.847	<.001	<.001	3	6
BRCA	FANCB →	+0.729	+0.610	<.001	<.001	3	6
BRCA	FOXM1 →	+0.960	+0.493	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006513 vs XRCC2 — LSCC

Explore this scatter interactively →