Membrane protein ectodomain proteolysis

Across TCGA patient cohorts, RNA activity of the Membrane protein ectodomain proteolysis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRP9, TIMP2, and ITGA5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane protein ectodomain proteolysis activity versus RRP9 in UCEC (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RRP9 →	-0.437	-0.077	.001	<.001	3	6
BRCA	TIMP2 →	+0.572	+0.030	<.001	<.001	3	6
BRCA	ITGA5 →	+0.536	+0.043	<.001	<.001	3	6
BRCA	SERPINB9 →	+0.619	+0.035	<.001	<.001	3	6
LSCC	MRPL14 →	-0.275	-0.046	<.001	<.001	3	6
LSCC	BRIP1_T989 →	-0.859	-0.055	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006509 vs RRP9 — UCEC

Explore this scatter interactively →