Membrane protein ectodomain proteolysis

Across TCGA patient cohorts, RNA activity of the Membrane protein ectodomain proteolysis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCQ-AS1, PRKCQ, and PILRA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane protein ectodomain proteolysis activity versus PRKCQ-AS1 in UCEC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRKCQ-AS1 →	+1.176	+0.221	<.001	<.001	3	4
UCEC	PRKCQ →	+1.728	+0.225	<.001	<.001	3	4
OV	PILRA →	+0.711	+0.146	<.001	.003	3	4
UCEC	TPST2 →	+0.755	+0.204	.001	.003	2	5
GBM	FOXM1 →	-0.857	-0.082	<.001	.006	3	4
GBM	SLC66A3 →	+0.437	+0.126	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006509 vs PRKCQ-AS1 — UCEC

Explore this scatter interactively →