Membrane protein ectodomain proteolysis

Across TCGA cell cohorts, RNA activity of the Membrane protein ectodomain proteolysis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAM10, DAG1, and C5orf46, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane protein ectodomain proteolysis activity versus ADAM10 in SKIN (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ADAM10 →	+0.794	+0.180	.001	.002	3	6
CNS	DAG1 →	+1.218	+0.205	.001	.008	1	7
LIVER	C5orf46 →	+3.645	+0.315	.006	.003	3	5
PANCREAS	HOPX →	+1.202	+0.179	.001	.005	2	6
BONE	SFXN4 →	-1.188	-0.200	.001	<.001	3	5
BONE	NUDT17 →	-0.752	-0.145	.003	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006509 vs ADAM10 — SKIN

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