GPI anchor metabolic process

Across TCGA patient cohorts, RNA activity of the GPI anchor metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LPCAT3, IGLV3-9, and NCF1C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GPI anchor metabolic process activity versus LPCAT3 in OV (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LPCAT3 →	+0.858	+0.300	<.001	<.001	3	3
LUAD	IGLV3-9 →	-1.641	-0.164	.001	.001	2	4
GBM	NCF1C →	-0.499	-0.114	.001	.008	3	3
GBM	IGHJ3P →	-1.196	-0.143	.008	<.001	3	3
COAD	IGKV2D-29 →	-1.496	-0.211	.001	.004	2	4
GBM	MRPL43 →	-0.193	-0.114	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006505 vs LPCAT3 — OV

Explore this scatter interactively →