Protein N-linked glycosylation

Across TCGA cell cohorts, RNA activity of the Protein N-linked glycosylation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMNB1, PSRC1, and DHFR, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein N-linked glycosylation activity versus LMNB1 in BONE (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	LMNB1 →	-0.955	-0.135	<.001	.007	3	7
LARGE_INTESTINE	PSRC1 →	-0.859	-0.160	.001	<.001	3	6
BLOOD_Leukemia	DHFR →	-0.905	-0.125	<.001	.002	3	6
STOMACH	MYG1 →	-1.080	-0.334	.001	<.001	3	6
BLOOD_Lymphoma	TUFT1 →	+2.245	+0.169	<.001	<.001	3	6
BLOOD_Leukemia	VSIR →	+1.867	+0.122	.009	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006487 vs LMNB1 — BONE

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