Protein methylation

Across TCGA patient cohorts, RNA activity of the Protein methylation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RALY, SMARCB1, and ADNP, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein methylation activity versus RALY in HNSC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RALY →	+0.307	+0.079	<.001	<.001	3	9
LSCC	SMARCB1 →	+0.274	+0.040	<.001	<.001	3	7
LSCC	ADNP →	+0.399	+0.045	<.001	<.001	3	7
LSCC	HNRNPU →	+0.263	+0.043	<.001	<.001	3	7
GBM	ILF2 →	+0.301	+0.035	.001	<.001	3	7
GBM	NONO →	+0.168	+0.030	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006479 vs RALY — HNSC

Explore this scatter interactively →