Protein methylation

Across TCGA patient cohorts, RNA activity of the Protein methylation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPC25, GINS1, and SGO1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein methylation activity versus SPC25 in UCEC (Pearson r = -0.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPC25 →	+1.130	+0.895	<.001	.001	3	7
UCEC	GINS1 →	+0.898	+0.784	.004	.005	3	6
HNSC	SGO1 →	+0.644	+0.721	<.001	.002	3	6
GBM	CDCA2 →	+0.880	+0.629	<.001	<.001	3	6
GBM	KIF20A →	+0.892	+0.818	<.001	<.001	3	6
LSCC	BRCA1 →	+0.678	+0.602	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006479 vs SPC25 — UCEC

Explore this scatter interactively →