Protein methylation

Across TCGA cell cohorts, RNA activity of the Protein methylation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR2E, MRPL52, and CHORDC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein methylation activity versus POLR2E in OVARY (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	POLR2E →	+0.942	+0.186	.001	.003	3	6
BLOOD_Myeloma	MRPL52 →	+1.067	+0.238	.001	.003	3	5
LUNG_NSCLC_LUAD	CHORDC1 →	+1.064	+0.206	<.001	.001	3	5
SKIN	ATAD3A →	+0.783	+0.172	.006	.003	3	5
LUNG_NSCLC_LUAD	BTG1 →	-1.293	-0.204	<.001	<.001	3	5
PANCREAS	SRSF3 →	+0.584	+0.215	.007	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006479 vs POLR2E — OVARY

Explore this scatter interactively →