Protein methylation

Across TCGA cell cohorts, RNA activity of the Protein methylation pathway is significantly associated with the protein abundance of multiple proteins, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ETF1, GSPT1, and RPL5, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein methylation activity versus ETF1 in OVARY (Pearson r = 0.68).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ETF1 →	+1.176	+0.215	<.001	<.001	3	15
STOMACH	GSPT1 →	+1.925	+0.277	<.001	.001	3	13
OVARY	RPL5 →	+0.636	+0.199	.001	.002	3	12
LUNG_SCLC	PAICS →	+1.332	+0.168	<.001	.001	3	12
OVARY	EIF3A →	+1.043	+0.209	<.001	<.001	3	11
LARGE_INTESTINE	NTMT1 →	+1.563	+0.257	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006479 vs ETF1 — OVARY

Explore this scatter interactively →