Protein sulfation

Across TCGA patient cohorts, RNA activity of the Protein sulfation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL8A1, FCGR3A, and C20orf194, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein sulfation activity versus COL8A1 in GBM (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COL8A1 →	+1.393	+0.495	.001	.004	2	5
BRCA	FCGR3A →	+1.541	+0.387	<.001	<.001	3	4
LUAD	C20orf194 →	+0.462	+0.173	.005	.006	3	3
GBM	CACNA1C-AS4 →	+0.541	+0.488	.007	.007	3	3
BRCA	HEPH →	+1.250	+0.301	.001	.006	3	3
LSCC	UGGT2 →	+0.497	+0.078	.006	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006477 vs COL8A1 — GBM

Explore this scatter interactively →