Protein deacetylation

Across TCGA cell cohorts, RNA activity of the Protein deacetylation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBBP4, SIAH3, and STRADA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBBP4 grouped by Protein deacetylation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RBBP4 →	-0.626	-0.324	.003	.002	3	6
LUNG_SCLC	SIAH3 →	-0.157	-0.164	.009	.004	1	6
KIDNEY	STRADA →	-0.190	-1.116	.006	.002	3	4
LARGE_INTESTINE	PFN1 →	-0.347	-0.243	.001	<.001	3	4
LARGE_INTESTINE	HDAC3 →	-0.203	-0.194	.004	.002	3	4
LUNG_SCLC	VDR →	-0.162	-0.193	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBBP4 by Protein deacetylation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →