Protein acetylation

Across TCGA cell cohorts, RNA activity of the Protein acetylation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR5, RBFA, and ATIC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein acetylation activity versus TLR5 in BLOOD_Lymphoma (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TLR5 →	-0.595	-0.196	.007	<.001	3	5
KIDNEY	RBFA →	+0.554	+0.887	.001	.008	3	4
CNS	ATIC →	+0.534	+0.889	.009	.002	3	4
BREAST	C6orf52 →	+0.853	+0.622	.005	<.001	3	4
BREAST	ZNF837 →	+0.561	+0.699	.008	.006	3	4
BLOOD_Lymphoma	BAMBI →	-1.308	-0.194	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006473 vs TLR5 — BLOOD_Lymphoma

Explore this scatter interactively →